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Sequestration of Veterinary Medicines in Soils

Sponsor:
Deutsche Forschungsgemeinschaft
Project number:
DFG KA 1139/13 FOR 566
Duration:
04.04.2005-28.03.2008
Project director:
Martin Kaupenjohann
Assistant:
Nadine Prey, Sabine Dumke
Partner:
A. Schäffer, Berndt-Michael Wilke, Harry Vereecken, K. Smalla, M. Matthies, J. Klasmeier, Michael Spiteller, S. Thiele-Bruhn, Wulf Amelung

Abstract

It is not the total concentration but the (bio)available portion of veterinary medicines that de¬termine toxicity, bioaccumulation, and leaching potential. With increasing contact time in soil, the bioavailability of antibiotics decreases, because secondary sorption reactions and diffusion into micropores withdraw them from biological contact and uptake. Such sequestration processes reduce acute toxicity but prolong the residence time. Our objective is to elucidate the molecular processes that control the sequestration of sulfadiazine and amoxicillin in soil. For this purpose, we will first apply sequential extractions on field- and laboratory aged samples to quantify the dynamic change of the sorption coefficients. Model systems, partly slurry-coated, and manipulated soil fractions are used for sorption hystereses and aging experiments to identify the key soil parameters that determine binding and aging of the compounds at different pH. Based on selected sorption isotherms, an identification of molecular binding reactions is then achieved by combining static and dynamic flow microcalorimetry with spectroscopic and pressure-jump relaxation techniques. The desorbing antibiotics are quantified using radioscintillation counting or liquid-state tandem mass spectrometry; the development of a solid-state bioassay is intended to detect in-situ available functional groups of adsorbed molecules.

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